I don’t think woodwind players ever get tired of discussing this subject, because the search for the perfect reed is so elusive. I don’t like synthetic reeds. I just don’t think you can get the same sound from a synthetic. They seem too artificial and buzzy to me–no warmth. There is something in the organic quality of a cane reed that is at the heart of a good saxophone sound, but that same organic quality is what makes finding and maintaining reeds so frustrating. Two of the best articles I have read on reeds are from Tom Alexander and Tim Price. Check out the respective links. Also, The Art of Saxophone Playing by Larry Teal has an excellent chapter on caring for and balancing reeds. Every serious saxophone player should have this book.
The best reed for me can vary from year to year and seems to have more to do with who has the best batch of cane this season rather than a specific brand. At the moment, reeds from Rigotti are working very well for me. These include Regal Queen, Francois Louis and Roberto’s Woodwind private label reeds, which are also by Rigotti. You can’t get them at your local music store, but they are readily available on line, and Roberto’s Woodwind in New York City sells them. Of the “name brands”, I have had the best luck with Vandoren, particularly the relatively new ZZ cut. I use mainly number 3’s on both alto and tenor.